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While high amounts of nicotine can cause jitteriness or anxiety, the withdrawals from nicotine from dependency also produce such effects as well as irritability, increased appetite, and intense anxiety

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Tobacco contains nicotine, a highly addictive drug

In small doses cobalt is fine for you (it makes up B12 which is great for all your organs) but when consumed in excess cobalt can cause nausea, heart conditions, and can even result in death (TSB)